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Image Search Results
Journal: Circulation
Article Title: Autoimmune Atrial Fibrillation
doi: 10.1161/CIRCULATIONAHA.122.062776
Figure Lengend Snippet: Electrophysiological phenotyping of mice with K ir 3.4 autoantibodies. A , Study design of the experimental autoimmune AF model with Balb/c mice. B , Representative surface ECG traces derived from limb leads I and II, recorded from a sham-immunized and K ir 3.4-immunized mouse. C , Bar graphs overlaid with dot plots present mean ECG interval values±SD recorded in sham- (n=14) and K ir 3.4-immunized mice (n=10). Statistical significance was determined using the Student t test (PR, QRS, QTc, and JTc) and Mann-Whitney U test (RR). D , Representative bipolar intracardiac electrogram recordings at the level of the right ventricle (RV) and right atrium (RA). STIM denotes right atrial stimulation. ECG in lead II configuration shows the corresponding surface ECG signals. E , Bar graphs overlaid with dot plots present mean intracardiac electrophysiological data±SD acquired in sham- (n=14) and K ir 3.4-immunized mice (n=10). Statistical significance was determined using the Student t test (SNRT, cSNRT, AERP, and AVERP) and Mann-Whitney U test (WCL). F , Bar graph shows the proportion of sham- (4 of 14) and K ir 3.4-immunized mice (8 of 10) with burst pacing–induced AF. Points indicate mean AF duration±SD ( P =0.214). Statistical significance was determined by Mann-Whitney U test (AF duration), and Fisher exact test was used to assess the induced AF rate. AERP indicates atrial effective refractory period; AF, atrial fibrillation; AVERP, atrioventricular effective refractory period; cSNRT, corrected sinus node recovery time; EGM, electrogram; EPS, electrophysiological study; SNRT, sinus node recovery time; and WCL, Wenckebach cycle length.
Article Snippet: The body temperature was kept at 37 °C with a heating pad, and all mice were continuously monitored with
Techniques: Derivative Assay, MANN-WHITNEY